Kapustin RV, Chepanov SV, Babakov VN, et al. - Pregnant patients with different types of diabetes mellitus (DM) were examined for serum concentration of leptin, adiponectin, resistin, and MCP-1 considering preconception planning and method of DM correction in 11–14th and 30–34th weeks of pregnancy. In this longitudinal, prospective study, 130 pregnant women were included and divided into the following comparison groups: type 1 DM (T1DM, n = 40), type 2 DM (T2DM, n = 35), GDM (n = 40), and the control group (n = 15). The T2DM insulin group exhibited the highest leptin level in the 1st trimester compared with the control due to gestational age, hence in the 3rd trimester, all groups appeared to have its serum concentrations higher than the healthy patients. All DM groups showed increased resistin levels in the 1st and 3rd trimesters compared with the control group. In the 1st trimester, T2DM insulin group had the lowest levels of adiponectin compared with T1DM and the control group while in the 3rd trimester, decline in adiponectin levels occurred alongside gestational age in DM patients and all the groups compared with the control group. T2DM group appeared to have higher MCP-1 levels than T1DM patients and the control group in the 1st trimester, whereas in the 3rd trimester, there was decline in MCP-1, correlating with BMI, preeclampsia and OGTT levels. Per findings, diabetic pregnancy is correlated with a high rate of adverse perinatal outcomes, which might develop due to more severe metabolic failures and further disturbances of adipokines expression.