Sadruddin S, Barnett B, Ku L, et al. - Researchers sought to determine actionable clinical and culture characteristics of IVF treatment that influence blastocyst developmental rate, with the goal of attaining optimal success. They conducted a retrospective observational study of 106 women undergoing IVF, regardless of prognosis, over a 6-month period from January 1, 2015 to June 31, 2015. When outcome was ≥ 40% high-quality blastocysts, treatment was defined successful. Findings revealed superior value of [AMH] for determining ovarian stimulation response and an actionable variable for stimulation dose management for optimizing blastocyst development in culture. Among individuals presenting with an [AMH] of ≥ 3.2 mg/ml, having a good prognosis, and developing > 12 mature follicles result in < 40% blastocysts when gonadotropin doses exceed 3,325 IU per treatment. IVF treatments for poor responders that present with infertility due to declined ovarian reserve, if managed appropriately, can yield more usable blastocyst per IVF treatment, thus raising rate of blastocyst developmental success and finally improving live birth rates.