Raghavan R, et al. - The topic of exploration here was the potential connection between multivitamin supplementation during pregnancy and biomarker measures of maternal plasma folate and vitamin B₁₂ levels at birth and child's Autism Spectrum Disorder (ASD) risk. A ‘U shaped’ relationship was disclosed between maternal multivitamin supplementation frequency and ASD risk. A correlation was reported among extremely high maternal plasma folate and B₁₂ levels at birth with ASD risk. The significance of consuming adequate folic acid and vitamin B₁₂ during pregnancy was not questioned. Nonetheless, new questions regarding the impact of extremely elevated levels of plasma folate and B₁₂ exposure in-utero on early brain development were raised.