Samsuddin S, Arumugam PA, Yahya A, et al. - Researchers examined whether maternal lipaemia influences neonatal anthropometrics in Malaysian mother-offspring pairs. In this prospective observational cohort study, they assessed 507 mothers: 145 with gestational diabetes mellitus (GDM), 94 obese with normal glucose tolerance (NGT)( pregravid BMI > 27.5 kg/m²) and 268 non-obese NGT. The analysis revealed an independent association of fasting triglyceride (Tg) > 95th centile (3.6 mmol/L) at screening OGTT with large for gestational age (LGA) after adjustment for maternal glucose, pregravid BMI and insulin sensitivity. In this well-treated GDM cohort with predelivery HbA_1c of 5.27%, an independent association of fasting glucose with BWR > 90th centile but not LGA status was observed. Findings suggest that in Asian offspring, maternal lipaemia, and GWG at a low threshold (> 10kg) adversely affect neonatal adiposity; this was observed independent of glucose/insulin resistance/pregravid BMI. Hence, these seem to be significant modifiable metabolic targets in pregnancy.