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Maternal height, gestational diabetes mellitus and pregnancy complications

Diabetes Research and Clinical Practice Jul 26, 2021

Chu AHY, Yuan WL, Loy SL, et al. - Researchers sought to test the glucose-overload hypothesis of artefactual gestational diabetes (GDM) diagnosis in shorter women during oral glucose tolerance testing (OGTT), by examining height-groups for correlations between height and maternal glycemia; and GDM and pregnancy complications. Among women from GUSTO (n = 1,100, 2009-2010) and NUH (n = 4,068, 2017-2018) cohorts, mid-gestation 75g 2-hour OGTT was conducted at two and three time-points, respectively. Using WHO-1999 criteria, GDM-1999 was diagnosed in 18.8% (GUSTO) to 22.9% (NUH) of women; and by WHO-2013 criteria, 21.9% (NUH) had GDM-2013. An increased odds of GDM-related pregnancy complications was recorded for only taller women. Paucity remains concerning an artefactual GDM diagnosis due to glucose-overload among shorter women.

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