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Maternal glycaemic control and risk of neonatal hypoglycaemia in type 1 diabetes pregnancy: A secondary analysis of the CONCEPTT trial

Diabetic Medicine Jun 20, 2019

Yamamoto JM, et al. - In the Continuous Glucose Monitoring in Type 1 Diabetes Pregnancy Trial (CONCEPTT), researchers studied the association between maternal glycemic control and neonatal hypoglycemia risk (defined as glucose concentration < 2.6 mmol/l and requiring intravenous dextrose) utilizing conventional and continuous glucose monitoring metrics. Participants in the study were 225 pregnant women and their liveborn infants. Investigators found that mothers of infants with neonatal hypoglycaemia had higher HbA1c and lower continuous glucose monitoring time-in-range during the second and third trimesters. Findings suggested an association of modest increments in continuous glucose monitoring time-in-target (5–7% increase) during the second and third trimesters with decreased risk for neonatal hypoglycaemia. While there is a need for more intrapartum continuous glucose monitoring data, the higher birth weight and skinfold measures associated with neonatal hypoglycaemia suggest that risk was related to fetal hyperinsulinemia prior to the immediate intrapartum.
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