Yuan WL, Lin J, Kramer MS, et al. - This study was attempted to analyze whether and how the maternal glycaemia during pregnancy is associated with cardiovascular risk markers in their children in GUSTO, a Singaporean birth cohort study. Researchers conducted a 75g oral glucose tolerance test and assessed fasting and 2-hr postprandial plasma glucose concentrations around 26 weeks’ gestation. WHO 1999 diagnostic criteria was applied to define Gestational diabetes mellitus. The child’s carotid intima-media thickness, carotid-femoral pulse wave velocity, aortic augmentation index and blood pressure (BP) were assessed at age 6 years. Multiple linear and logistic regressions were applied to analyze relationship of maternal glycaemia during pregnancy with cardiovascular risk markers in their children. This research included 479 mother-child dyads for performing the analysis. The evidence showed that, among mothers without pre-existing diabetes, association was found between higher glycaemia during pregnancy and mild structural and functional vascular changes in their children at age 6 years across a continuum. These outcomes support the necessity to monitor maternal glycaemia during pregnancy even in absence of pre-existing diabetes or diagnosed gestational diabetes.