Geurtsen ML, Wahab RJ, Felix JF, et al. - This study was carried out to assess whether maternal glucose concentrations across the full range may have persistent effects on offspring liver fat accumulation. Researchers conducted a multi-ethnic population-based prospective cohort study including a total of 2,168 women to measure maternal early-pregnancy glucose concentrations at a median of 13.1 weeks gestation (95% range 9.6-17.2 weeks). Magnetic resonance imaging measured liver fat fraction at 10 years. Analyses among all mothers with different ethnic backgrounds and those of European ancestry only were conducted. The results showed that maternal early-pregnancy glucose concentrations were only among mothers of European ancestry correlated with offspring non-alcoholic fatty liver disease. As per the findings, the relationships of higher maternal early-pregnancy glucose concentrations with offspring of non-alcoholic fatty liver disease may differ between ethnic groups.