Guelfi KJ et al. – This study investigated the circulating concentrations of various adipokinases associated with insulin resistance in pregnant women and determined whether their concentrations are affected in women with gestational diabetes mellitus (GDM). The authors concluded that in pregnant women with a history of GDM, maternal glucose and adipokine profile were altered and resulted in development of recurrent disease.

Methods

• This study included 123 non–diabetic women with a history of GDM in a previous pregnancy and had blood drawn at 14 and 28 weeks of pregnancy for GDM diagnosis.

Results

• A decrease in maternal adiponectin concentrations and an increase in leptin and resistin levels were observed with advancing pregnancy.
• About 42% of pregnant women developed GDM at 28 weeks; their fasting and postprandial glucose levels were already increased at week 14 while adiponectin concentrations were low.
• At each time point other adipokines remained similar between the groups.