Miyoshi T, et al. - Researchers investigated the possible efficacy of maternal serum biomarkers in diagnosing fetal heart failure in fetuses with congenital heart defects or arrhythmias via an exploratory cross-sectional study at a tertiary pediatric cardiac center. They analyzed a total of 50 singletons with fetal congenital heart defects or arrhythmias and 50 controls who were registered in the National Cerebral and Cardiovascular Center Biobank from 2013 to 2016. As per outcomes, fetal heart failure was evident in association with maternal serum concentrations of tumor necrosis factor-α, vascular endothelial growth factor-D, and heparin-binding epidermal growth factor-like growth factor.