Maternal arterial stiffness in hypertensive pregnancies with and without small‐for‐gestational‐age neonate
Ultrasound in Obstetrics & Gynecology Jun 10, 2020
Perry H, Gutierrez J, Binder J, et al. - Given the value of arterial stiffness as prognostic marker of cardiovascular disease in the general population, researchers here examined whether maternal arterial stiffness differ between hypertensive pregnancies with, and those without, a small‐for‐gestational‐age (SGA) neonate and normotensive control pregnancies. In this prospective cohort study, they analyzed 69 patients with hypertensive disorders of pregnancy (HDP) who delivered a SGA neonate, 129 with HDP who delivered a normally grown neonate and 220 healthy controls. Observations revealed significantly higher aortic AIx in pregnancies complicated by HDP with, and those without, a SGA neonate vs uncomplicated normotensive pregnancies. Pregnancies complicated by HDP with a SGA neonate showed the highest aortic AIx, indicating a progression in severity of arterial stiffness abnormality with a worsening clinical picture. Findings thus most likely indicate systemic reduced vascular compliance and raised systemic vascular resistance in pregnancy complicated by HDP.
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