Letourneau N, et al. - In this study, experts investigated the correlation between four patterns of probable perinatal depression (mother depressed, father depressed, both depressed, neither depressed) in co-parenting mothers and fathers and their children’s internalizing and externalizing behaviors at 24 and 36 months of age (n = 634 families) and reviewed the impact of sociodemographic, risk and protective factors. While probable perinatal depression in mothers prognosticated 2 and 3-year-old children’s behavioral problems, the co-occurrence of depression in mothers and fathers had a progressed relationship with internalizing behavioral problems, subsequent to taking into consideration the sociodemographic, risk and protective factors. Moreover, in preventing and treating perinatal depression, healthcare providers are inspired to take into account the whole family.