Mensink-Bout SM, et al. - Researchers examined 4951 children and their mothers to assess how 25-hydroxyvitamin D concentrations in mid-gestation and at birth are associated with lung function, asthma, inhalant allergic sensitization and inhalant allergy at school-age. Results suggest the association of higher maternal 25-hydroxyvitamin D concentrations in mid-gestation with a lower forced expiratory volume in 1 second/FVC (FEV₁/FVC) and forced expiratory flow after exhaling 75% of FVC (FEF₇₅), but not with asthma, after additional adjustment for 25-hydroxyvitamin D at the age of 6 years. This study supported the inconsistent results of previous observational studies indicating the complexity of the associations of early life vitamin D with respiratory and allergy outcomes.