Cauldwell M, et al. - Researchers performed a retrospective cohort study investigating maternal and perinatal outcomes in pregnancies complicated by Loeys–Dietz syndrome (LDS). They identified 20 pregnancies in 13 women with LDS with one miscarriage, one termination of pregnancy, and 18 live births. Only one of eight women who were diagnosed prior to pregnancy underwent preconception counseling. This cohort had no aortic dissections during pregnancy or postpartum. They commonly reported obstetric complications, including postpartum hemorrhage (33%) and preterm delivery (50%). Elective cesarean section was done in 14/18 (78%) of deliveries, at a median gestational age at delivery of 37 weeks. Admission to the neonatal unit was reported for over half the infants (56%) following delivery. Multidisciplinary specialist management throughout pregnancy is recommended for these women. Preconception counseling in these women should be encouraged to make informed decisions around pregnancy risk and outcomes. Balancing early elective preterm delivery against a high infant admission rate to the neonatal unit is recommended.