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Maternal age and the risk of gestational diabetes mellitus: A systematic review and meta-analysis of over 120 million participants

Diabetes Research and Clinical Practice Feb 06, 2020

Li Y, et al. - Via searching three electronic databases [PubMed, Embase, and Web of Science] for publications from inception to July 2018, researchers sought to assess and quantify the risk for gestational diabetes mellitus (GDM), one of the most common medical complications of pregnancy, according to maternal age. Using generalized least squares regression, a dose-response analysis was performed. The present meta-analysis comprised of 24 studies. According to results, GDM risk for the overall population, Asian, and Europid increased by 7.90%, 12.74%, and 6.52%, respectively, for each one-year increase in maternal age from 18 years. Subgroup analyses found that Asian women had a significantly higher risk of developing GDM than Europid women from the age of 25. The authors concluded that the risk of GDM rises linearly with successive age-groups.
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