Bae H, et al. - Given the likelihood of young adult college students in the United States to be affected by marijuana liberalization trends, researchers here sought to determine change in students’ marijuana use in US states that did (n = 234,669 in seven states) or did not (n = 599,605 in 41 states) enact recreational marijuana legalization (RML) between 2008 and 2018. They administered a cross-sectional National College Health Assessment survey twice yearly from 2008 to 2018 in a total of 587 4-year colleges and universities in 48 US states. The analysis revealed a general trend towards greater increases in marijuana use by college students in US states that enacted recreational marijuana legislation from 2012 to 2017. Students who were female, residing off-campus and aged 21 years and older exhibited stronger RML effects in interaction models. In the earliest states to enact RML (2012), the use prevalence increased in the second through the sixth year post-RML compared with pre-RML. The second legalization group (2015) exhibited raises in the first and second year post-RML and greater raises in the third year. They noted increases in both years after RML in the later states (2016–17).