Beyene HB, Hamley S, Giles C, et al. - In this community based cross-sectional study, researchers determined plasma lipid species correlated with indices of insulin resistance and assessed the lipidome response to an oral glucose tolerance test (OGTT). Using liquid chromatography tandem mass spectrometry, plasma samples (collected at 0 and 120 min during an OGTT) from non-obese, young adults aged 18-34 years (n = 246) have been analyzed. During an OGTT, the plasma lipidome and changes in lipid levels were linked to indices of insulin resistance. Such results emphasize the role of molecular lipid species in insulin resistance pathogenesis and likely crosstalk between insulin resistance and lipid metabolism regulation according to gender.