Wotman M, Ghaly M, Massaro L, et al. - In this retrospective chart review, researchers examined the multidisciplinary management of patients with human papilloma virus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC) and an incomplete nodal response on restaging PET/CT following definitive chemoradiation (CRT). The study sample consisted of patients diagnosed with node-positive HPV-associated OPSCC from 2012 to 2017, who had definitive upfront CRT, and had an incomplete response on posttherapy PET/CT according to NCCN criteria. According to findings, 74 patients have been identified with node-positive HPV-associated OPSCC. In the final case series, 20 patients with incomplete neck response on PET/CT according to NCCN criteria have been involved. This institutional experience supports the concept of a elevated neck dissection limit in this low-risk population; only 1 out of 20 patients with suspect results of PET/CT had residual neck disease. In addition, as present algorithms do not universally include HPV status, these patients should be controlled by a multidisciplinary tumor board. Finally, with modifications in terminology and consideration of FDG-avidity at the main site and on pretherapy scans, the use of restaging PET/CT to guide neck management can be enhanced.