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Management of suspected opioid overdose with naloxone in out-of-hospital settings: A systematic review

Annals of Internal Medicine Dec 01, 2017

Chou R, et al. - The intent of the authors was to synthesize evidence on the effects of naloxone route of administration and dosing for suspected opioid overdose in out-of-hospital settings on mortality, reversal of overdose, and harms. Additionally, they strived to prove the need for transport to a health-care facility after reversal of overdose with naloxone. The results demonstrated similar efficacy between higher-concentration intranasal naloxone (2 mg/mL) with that of intramuscular naloxone for reversal of opioid overdose. No variations were noted in the adverse events. It was also disclosed that nontransport after reversal of overdose with naloxone possibly correlated with a low rate of serious harms. However, this research did not assess the risks of transport vs nontransport.
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