Menditto VG, et al. - Researchers investigated efficacy and safety of the interventional protocol implemented for spontaneous soft-tissue hemorrhage secondary to anticoagulant therapy in their department. Eighty consecutive patients with spontaneous, severe, life-threatening soft-tissue hemorrhage (SSTH) secondary to anticoagulation therapy received a structured clinical pathway, including aggressive resuscitation, reversal of coagulopathy when indicated, Interventional Radiology procedures by transcatheter embolization (TE), clinical observation and repeated laboratory controls. As per outcomes, this pathway that included TE appeared to be an effective and safe method to manage these patients.