Palesh O, et al. – In this review, authors summarized the data on cancer–related fatigue, insomnia, and cancer–related cognitive impairment incidence and prevalence among breast cancer patients and survivors and also recent research findings on pharmaceutical, psychological, and exercise interventions that have demonstrated efficacy in the treatment of these side effects. This review uncovered that most current pharmaceutical interventions tend to ameliorate symptoms only temporarily without addressing the underlying causes. Exercise and behavioral interventions are consistently more effective at managing chronic symptoms and possibly address an underlying etiology.

• Cancer–related fatigue, insomnia, and cancer–related cognitive impairment are commonly experienced symptoms that share psychological and physical manifestations.
• One or more of these symptoms will influence nearly all patients at some point amid their course of treatment or survivorship.
• These side effects are burdensome and decrease patients' quality of life well beyond their cancer diagnosis and related care treatments.
• Cancer–related fatigue, insomnia, and cancer–related cognitive impairment are likely to have multiple etiologies that make it difficult to identify the most effective method to manage them.