Kolokythas A, et al. - Researchers reviewed the medical management for osteoradionecrosis (ORN) and assessed the reported outcomes with the use of pentoxifylline and tocopherol (PENTO), by means of a systematic review and meta-analysis. They used the likelihood function to combine the studies and estimate the proportion and standard deviation of each outcome by the maximum likelihood estimation. In the treatment of ORN of the jaws, the use of PENTO is suggested. As per data, 60 patients remained the same, they lost 10 patients to the follow-up, and 15 demonstrated the progression of the disease.