Chiang WF, Liu SY, Lin JF, et al. - Sixty-two individuals with oral carcinomas and 555 with oral potentially malignant disorders (OPMDs) who were detected through screening, were enrolled in this study in order to investigate the distribution of OPMDs and follow-up outcomes through the screening outcomes from a single institution in a region with a high betel quid chewing predominance. Data reported that the 5-year cumulative cancer-free interval rate was 94.1%, and the annual malignant transformation rate was 1.16%. Investigators found that the rate of interval carcinoma development was 13.6%, 5.7%, 4.6%, 12.1%, and 21.3% from Candida hyperplasia, oral submucous fibrosis, homogeneous leukoplakia, non-homogenous leukoplakia, and verrucous hyperplasia, respectively. Well-designed system for risk assessment, treatment, and monitoring can contribute to earlier detection of cancer and thereby decrease mortality and morbidity. Heavy betel quid chewing, verrucous hyperplasia, and surgery refusal were significant independent risk factors for interval carcinoma development.