Yang YJ, et al. - This article was written with the objective to research whether patients with type 2 diabetes mellitus (T2DM) and H. pylori infection had more severe corpus gastric inflammation and higher prevalence of precancerous lesions than non-diabetic controls. It was concluded that the patients with type 2 diabetes mellitus and H. pylori infection had more severe corpus gastric inflammation than non-diabetic controls. Moreover, male gender and non-insulin users of T2DM patients were predisposed to have corpus-predominant gastritis after H. pylori infection.

Methods

• In this study, they screened total of 797 patients with type 2 diabetes mellitus for H. Pylori, of whom 264 had H. Pyloriinfection .
• Of these patients, 129 received esophagogastroduodenoscopy to obtain topographic gastric specimens for gastric histology according to the modified Updated Sydney System, corpus-predominant gastritis index (CGI), Operative Link on Gastritis Assessment, and Operative Link on Gastric Intestinal Metaplasia Assessment.
• Non-diabetic dyspeptic patients who had H. Pylori infection affirmed by esophagogastroduodenoscopy were enlisted as controls.

Results

• The current study showed that the male as well as total T2DM patients had higher acute/chronic inflammatory and lymphoid follicle scores in the corpus than non-diabetic controls (p<0.05).
• In contrast, the female T2DM patients had higher chronic inflammatory scores in the antrum than the controls (p<0.05).
• The males had significantly higher rates of CGI than the females (p<0.05) in T2DM patients.
• Multivariate logistic regression investigation demonstrated that male patients (odds ratio: 2.28, 95% confidence interval: 1.11-4.69,p=0.025) and non-insulin users (odds ratio: 0.33, 95% confidence interval: 0.15-0.74,p=0.007) were independent factors for the presence of CGI in the H. Pylori-infected patients with type 2 diabetes mellitus.