Shabanzadeh DM, Clausen S, Maigaard K, et al. - This study was attempted to ascertain the risk of complications requiring treatment following male circumcision by health-care professionals and to explore the impact of participant characteristics, type of circumcision, and study design. Researchers distinguished studies through systematic searches in online databases (MEDLINE, EMBASE, and CENTRAL) and hand searches. Random-effects meta-analysis was conducted to ascertain the risk of circumcision complications and mixed-effects meta-regression analyses to explore the impact of participant characteristics, type of circumcision, and study design. Methods were pre-specified in a registered protocol (Prospero CRD42020116770) and according to PRISMA guidelines. In the analysis, 351 studies with 4.042.988 participants were included. The findings demonstrated that circumcision complications occur in about four per hundred circumcisions. It has been reported that higher risks of complications were ascertained by therapeutic circumcisions and by childhood age when compared to infants. Further trials are needed to evaluate therapeutic and childhood circumcisions separately.