Xu MJ, et al. - Researchers evaluated the changes resulting from the American Joint Committee on Cancer (AJCC) eighth edition for cutaneous squamous cell carcinoma (SCC) and assessed the relevant excluded factors. Findings suggested a significant correlation of in-transit metastasis with locoregional recurrence, overall survival (OS), and cause-specific mortality. An association of cause-specific mortality with positive margin, in-transit metastasis, and the seventh edition dichotomized T classification and overall stage was noted in univariate analysis (limited by number of events).