Buisson A, et al. – The current study's goal was to compare the accuracy of Magnetic resonance index of activity (MaRIA) and Clermont score in evaluating Crohn’s disease (CD) mucosal healing. In detecting CD endoscopic ulcerations, MaRIA and Clermont score was equally effective, supporting their use as therapeutic endpoints.

• The clinicians enrolled 44 CD patients who underwent prospectively and consecutively MRI and colonoscopy.

• Considering 207 segments, MaRIA > 7 and Clermont score > 8.4 showed substantial accuracy to identify endoscopic ulcerations (73.9% and 74.0%, respectively) and presented with high specificity (82.1% and 81.3%) and high negative predictive value (NPV) (82.1% and 82.4%) for MaRIA and Clermont score, respectively.
• With a specificity of 82.0% and 80.0%, the sensitivity for detecting deep ulcerations was 90.9% for both MaRIA > 11 and Clermont score > 12.5, respectively.
• Deep MRI remission predicted mucosal healing with specificity = 85.3% and NPV = 85.3% according to Barcelona criteria (no segmental MaRIA > 7), and specificity = 88.2% and NPV = 85.7% according to Clermont criteria (no segmental Clermont score > 8.4) among 44 patients.
• Moreover, according to Barcelona criteria (no segmental MaRIA > 11), MRI remission predicted mucosal healing with specificity = 76.5% and NPV = 86.7%, and specificity = 79.4% and NPV = 84.4% according to Clermont criteria (no segmental Clermont score > 12.5).