Augellia R, et al. - Forty-seven patients who underwent an advanced-MR study were analyzed to assess any possible correlation between the presence of Isocitrate DeHydrogenase 1 mutation (IDH1m) and specific diffusion tensor imaging (DTI) metrics, such as fractional anisotropy (FA), mean diffusivity (MD), radial diffusivity (RD) and axial diffusivity (AD), followed by surgical intervention with a subsequent histologic diagnosis of high-grade glioma (HGG) to assess the correlation with the IDH1 mutation, the ratio between tumor and normal tissue was measured, for each DTI metrics. A positive correlation with IDH1 status and RD and MD data and no correlation between IDH1 status and FA and AD was noted favoring the need for a multimodal advance evaluation of HGG. Hence, in order to better identify the lesions and to alter treatment and follow up, the analysis of IDH1 mutation status by DTI metrics is, nonetheless, considered helpful.