Wu YY, et al. - In this nationwide population-based retrospective study, the correlation between MgO use and hip fracture risk was evaluated in the elderly (age > 65 years). They enrolled 26,069 individuals with and 26,069 without MgO use after propensity score matching between 1996 and 2013. Hip fracture was the primary endpoint. They applied multivariate Cox proportional hazards regression models to estimate incidences and risk of hip fracture [hazard ratio (HR)] after adjusting for age, gender, comorbidities, and medications. They noted that 1547 and 1107 cases developed a hip fracture during the mean follow-up duration of 4.8 years in the MgO cohort and 5.7 years in the non-MgO cohort, respectively. In comparison with the non-MgO cohort, the cumulative incidence of hip fracture was significantly higher in the MgO cohort. In the elderly, MgO use is an independent risk factor for hip fractures.