Gu X, Mao Y, Shi C, et al. - In order to determine the detailed attributes of MAGEC2 in hepatocellular carcinoma (HCC), researchers focused on MAGEC2 mRNA expression in liver cancer, using The Cancer Genome Atlas and the Gene Expression Omnibus databases. They investigated the role of MAGEC2 in HCC development by employing the short hairpin (sh)RNA-mediated knockdown of MAGEC2 in HCC cell lines. HCC tissues vs noncancerous tissues exhibited a remarkably higher level of MAGEC2 expression. Moreover, both in vitro and in vivo, a series of HCC malignant behaviours was inhibited by sh-MAGEC2. Overall, MAGEC2 was identified as a new prognostic marker for HCC. Through inducing epithelial-mesenchymal transition, MAGEC2 was shown to have significantly promoted HCC tumourigenesis. MAGEC2 may be a promising therapeutic target in HCC.