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MAFLD identifies patients with significant hepatic fibrosis better than NAFLD

Liver International Oct 07, 2020

Yamamura S, Eslam M, Kawaguchi T, et al. - This research was sought to correlate the diagnostic accuracy of the metabolic associated fatty liver disease (MAFLD) definition vs the existing non-alcoholic fatty liver disease (NAFLD) criteria to identify patients with significant fibrosis and to characterize the effect of mild alcohol intake. Researchers included 765 Japanese individuals with fatty liver (median age 54 years). They diagnosed MAFLD and NAFLD in 79.6% and 70.7% of patients, respectively. Logistic regression and decision‐tree analyses were applied to examine factors associated with significant fibrosis. The MAFLD definition better distinguishes a group with fatty liver and via non‐invasive tests, significant fibrosis was evaluated. Moreover, even mild alcohol consumption is correlated with the worsening of hepatic fibrosis measures, in patients with MAFLD.

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