Costa JV, Moura-Coelho N, Abreu AC, et al. - Researchers conducted this national multicenter, observational, exploratory, retrospective cohort study to assess the presence of macular edema secondary to retinal vein occlusion (RVO)—both central retinal vein occlusion and branch retinal vein occlusion—3 years after diagnosis in patients who had intravitreal therapy and to identify potential prognostic factors and biomarkers of persistent macular edema. The sample consisted of 104 consecutive patients with macular edema secondary to RVO diagnosed from January 2014 to December 2015 with a minimum 3-year follow-up time. Intravitreal therapies in RVO patients produce successful long-term anatomical and functional results. Throughout the entire follow-up, anatomical success and visual gains seen in the first year were maintained, though DRIL is a major risk factor for recurrence.