Hou H, et al. - Researchers used a cross-sectional study to determine and compare the ganglion cell complex (GCC) thickness and macula vessel density in pre-perimetric and early primary open angle glaucoma (POAG) eyes. They examined a total of 57 healthy eyes, 68 pre-perimetric and 162 early POAG eyes enrolled in the Diagnostic Innovations in Glaucoma Study. Findings revealed detectable dropout with regard to both GCC thinning and macula vessel density in pre-perimetric and early POAG eyes. In early perimetric POAG, a greater GCC loss was noted as compared with macula vessel density loss. However, in the detection of early glaucoma, similar efficiency of optical coherence tomography angiography (OCT-A) and OCT measurements was observed.