Kristensen MD, et al. - Hepatic and adipose tissue macrophage content in subjects with obesity were investigated. Moreover, the authors aimed to examine the role of adipose tissue macrophages in weight loss-induced improved insulin sensitivity (IS). They demonstrated that for weight loss-induced IS improvements, decreased subcutaneous (SAT) macrophage content was not a primary driver. However, a better hepatic CD163 and CD206 macrophage profile could contribute to improved glycemic control and for visceral (VAT) macrophage markers SAT macrophage markers were not predictive.