Lymphocyte-to-monocyte ratio and neutrophil-to-lymphocyte ratio independently predict survival in resected small bowel adenocarcinoma
Journal of Clinical Oncology Feb 04, 2019
Huffman BM, et al. - In 93 retrospectively identified patients with complete follow up data who had resection for stage I-III small bowel adenocarcinoma, researchers assessed the factors associated with survival. Controlling for age, gender, location of tumor, tumor size, tumor stage, and adjuvant therapy, Cox proportional hazards were carried out. Among participants, 65 years (range 32-90) was the median age at diagnosis, 61% were males, and median tumor size was 4.5 cm. There were 20, 36, and 37 patients with stage I, stage II, and stage III disease, respectively, for which median overall survival (OS) was 151 months, 104 months, and 44 months, respectively. Presurgical lymphocyte to monocyte ratio (LMR) > 4.0, presurgical neutrophil to lymphocyte ratio (NLR) < 8.0, and tumor size < 7.5 cm were identified as independent predictor factors in a multivariate analysis. Overall, LMR and NLR were found to be independently predictive of survival in patients with resected small bowel adenocarcinoma.
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