Kolz JM, Rainer WG, Wyles CC, et al. - The outcomes of total knee arthroplasty (TKA) in patients with lymphedema were compared with those in a matched cohort with primary osteoarthritis. Primary TKA was performed on 144 knees with a preceding diagnosis of ipsilateral lymphedema. The match cohort comprised a group of knees without lymphedema undergoing primary TKA. Outcomes suggested correlation of presence of lymphedema with increased risk of revision, reoperation, and infection. Data gained thereby underscore the necessity for appropriate patient counseling and the necessity for further investigation into the effects of preoperative and postoperative optimization of lymphedema management in the TKA setting.