Chiappetta M, et al. - Researchers investigated how the number of resected and metastatic lymph nodes in non-small-cell lung cancer (NSCLC) influences the prognosis via evaluating the impact of lymphadenectomy in addition to the already validated variables in NSCLC survival. They retrospectively analyzed data on 4858 patients with NSCLC undergoing anatomical lung resection and hilomediastinal lymphadenectomy in 6 institutions. The median number of resected lymph nodes was 17 (range 6–85) and of metastatic lymph nodes was 2 (1–36). In multivariable analysis, longer overall survival (OS) rates were noted in correlation with age, gender, pathological stage, R0 resection, type of surgery and number of resected lymph nodes (NR); the same variables plus tumor grading were noted to be further related to disease-free survival (DFS). Outcomes establish the strong prognostic value of the number of resected lymph nodes in NSCLC. Both OS and DFS could be predicted with an NR cut-off value of 40%, particularly.