Pitto F, Zoppoli G, Scabini S, et al. - In a large retrospective, monocentric, series of post-neoCRT-RC individuals, researchers intended to investigate the importance of lymph node (LN) number, ratio and surface area in predicting metastases, overall survival (OS) and disease-free survival (DFS). This study included a total of 104 individuals with RC who underwent total mesorectal excision, after standard neoadjuvant chemoradiotherapy (neoCRT). This study obtained the following data regarding LNs: total numbers; number with metastases; LNratio (metastatic/total); maximum diameter; surface area. There was a statistically significant relationship between LN number and DFS. The outcomes of this study displayed that LN number, LN ratio, and LN surface area are important prognostic factors in neoCRT-RC and in particular finding ≤ 9 or > 20 LNs is prognostically adverse.