Luteinizing hormone and insulin resistance in menopausal patients with adrenal incidentalomas: The cause-effect relationship?
Clinical Endocrinology Apr 20, 2018
Marina LV, et al. - Researchers gauged the correlation between luteinizing hormone (LH) and insulin resistance (IR); adrenal tumour size (ATS) and IR; LH and cortisol after the 1 mg overnight dexamethasone test (1 mg DST); and ATS and 1 mg DST cortisol in adrenal incidentalomas (AI) patients. It was performed in the Clinic for Endocrinology, Diabetes and Metabolic Diseases in Belgrade, Serbia. Luteinizing hormone and ATS exhibited a prominent positive association with homeostasis model assessment (HOMA-IR) and 1 mg DST cortisol in menopausal patients with AI and possible autonomous cortisol secretion (P ACS). Thus, a possible cause-effect link was determined between LH and insulin in patients with AI and (P)ACS, providing evidence of their involvement in adrenal tumourigenesis and steroidogenesis.
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