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Lupus low disease activity state achievement is important for reducing adverse outcomes in pregnant patients with systemic lupus erythematosus

The Journal of Rheumatology May 05, 2021

Kim JW, Jung JW, Kim HA, et al. - This study was undertaken to investigate the frequency and risk factors of complications during pregnancy in women with systemic lupus erythematosus (SLE). Researchers obtained medical records of patients with SLE and age-matched controls at Ajou University Hospital. They compared clinical features and pregnancy complications in women with SLE with those of the controls. The predictors of adverse maternal and fetal outcomes were ascertained by performing multivariate logistic regression analysis. They examined 163 pregnancies in patients with SLE and 596 pregnancies in the general population; there were no significant differences regarding demographic characteristics. The data exhibited that pregnant women with SLE have a higher risk of adverse pregnancy outcomes. According to the findings, pregnancies are recommended to be delayed until achieving low Lupus Low Disease Activity State and should be closely monitored with the lowest possible dose of corticosteroid.

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