Aalstad LT, et al. - Researchers performed this prospective cohort study to investigate if longitudinal change in 6-minute walk distance (6MWD) among patients with chronic obstructive pulmonary disease (COPD) could be predicted by the inspiratory-to-total lung capacity (IC/TLC) ratio, a measure of lung hyperinflation that is associated with exercise intolerance. Participants included 389 patients aged 40–75 years with clinically stable COPD in Global Initiative for Chronic Obstructive Lung Disease stages II-IV. Follow-up revealed that patients with less lung hyperinflation at baseline maintained their functional exercise capacity, whereas, a significant reduction was observed for patients with increased lung hyperinflation.