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Lung function and pulmonary vascular resistance are not associated in 6-year-old children born extremely preterm

Acta Pediatrica Oct 03, 2019

Mohlkert LA, Sjöberg G, Rydberg A, et al. - Since children born preterm were at increased risk of reduced lung function, researchers explored the connection between lung function and pulmonary vascular resistance. From a population-based cohort born in 2004-2007, participants were selected. They assessed 66 children born at 22-26 weeks of gestational age at a mean age of 6.7 years. Despite large variations in lung function with forced vital capacity (FVC) z-scores ranging from -4.6 to +2.8, no connections were found between lung function and pulmonary arterial pressure, right ventricular structure or function. Children with higher FVC z-scores and higher forced expiratory volume in one-second z-scores showed larger pulmonary arteries. It is not possible to indicate routine echocardiographic evaluation of extremely preterm children at age 6.5 years.
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