Paquette M, et al. - In a cohort of genetically-confirmed heterozygous familial hypercholesterolemia (FH) patients, researchers assessed the value of an LPA variant, rs10455872, vs lipoprotein (a) (Lp(a)) concentration as predictors for the prevalence of cardiovascular disease (CVD) and age of the first CVD event. Using an enzyme-linked immunoassay kit, they measured Lp(a) total particle mass. They used an exome chip genotyping method to obtain rs10455872 genotype. In this study, the LPA variant rs10455872 was identified as a good predictor of premature CVD risk as well as a significant predictor of the age of the first CVD event in FH. Further reduction in CVD risk could be seen in relation to targeting Lp(a) in FH subjects.