Joling M, et al. - Experts comparatively analyzed ¹²³I-N-ω-fluoropropyl-2β-carbomethoxy-3β-(4-iodophenyl)nortropane (¹²³I-FP-CIT) binding to the striatal dopamine and the extrastriatal serotonin transporter (DAT and SERT, respectively) between Parkinson's disease (PD) and dementia with Lewy bodies (DLB). The intention was to obtain additional insight into the pathophysiology of the 2 diseases. Data disclosed that ¹²³I-FP-CIT binding in PD patients was considerably lower in the bilateral posterior putamen than in DLB patients. Hence, a similar involvement of serotonergic structures was revealed in the degenerative process in PD and DLB.