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Lower risk of stress fractures in young adults with ADHD under chronic treatment with methylphenidate

Bone Oct 02, 2018

Schermann H, et al. – Investigators conducted this study to evaluate the association of methylphenidate (MP) use with the incidence of stress fractures (SF) in a cohort of healthy conscripts aged 18–25 years who served for ≥ 12?months between 2008 and 2017. They divided participants into five groups: those without attention-deficit/hyperactivity disorder (ADHD); those with a diagnosis of ADHD who were untreated; and those with ADHD and prescriptions of 1–90, 91–180, or 181+ tablets during the study period. Outcomes revealed that the risk of stress fractures was low with concurrent MP use. The findings in this population challenged the previous basic and epidemiological research demonstrating an adverse effect of MP on bone mass.

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