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Lower albumin level and longer disease duration are risk factors of acute kidney injury in hospitalized children with nephrotic syndrome

Pediatric Nephrology Feb 04, 2021

Yang EM, Yoo KH, Ahn YH, et al. - Researchers undertook this retrospective multicenter study to determine incidence, clinical profiles, as well as risk factors of acute kidney injury (AKI) among hospitalized children suffering from nephrotic syndrome (NS). In this nationwide study, 14 pediatric nephrology centers in Korea took part. This analysis involved 363 children with NS who were hospitalized 574 times. In 93 admissions (16.2%) of 89 patients, the occurrence of AKI was reported. In this study population, AKI was not uncommon and its incidence was estimated to be 16.2%. Longer disease duration, lower albumin level, and methylprednisolone pulse therapy were identified as risk factors for AKI. Children with NS having these characteristics deserve more strict scrutiny for the development of AKI.

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