He X, et al. - Researchers undertook this cross-sectional analysis to clarify if serum sirtuin 1 (Sirt1) levels in asymptomatic populations are related to coronary atherosclerosis plaque features. Whether Sirt1 serum levels could serve as predictors of high-risk coronary plaques revealed via computed tomography angiography (CTA), was also determined. This study included patients from non high-risk plaque (HRP) group (control group) and HRP group. Patients in the HRP group vs those in the control group exhibited lower Sirt1 serum levels. In the univariate analysis, an independent link with HRP was shown by gender, hyperlipidemia, age, the total cholesterol to high-density lipoproteincholesterol (HDL-C) ratio, HDL-C, apolipoprotein B and Sirt1. For HRP, area under curve of the univariate model was estimated to be 0.848. The estimated specificity and sensitivity were 75.4% and 75.2%, respectively, and the estimated negative predictive value and positive predictive value were 83.0% and 66.2%, respectively. In people with low–intermediate Framingham Risk Score, HRP was predicted by low serum level of Sirt1, this suggests a possible predictive role of Sirt1 in the plaque screening prior to coronary CTA.