Spivak I, et al. - In a multicenter cohort of adult patients with acute liver failure (ALF) and in acetaminophen (APAP)-induced ALF mouse model, researchers analyzed iron metabolism parameters. A representative subset of 121 ALF adults (including 66 APAP-related subjects) had baseline serum samples tested for ferritin, transferrin, iron, and hepcidin. In adults with ALF, several serum iron parameters significantly associate with 3-week results. Hepcidin, among them, declines early during experimental APAP-induced ALF, is an independent predictor and could be a useful component of future prognostic scores.