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Low rate of spontaneous closure in premature infants discharged with a patent ductus arteriosus: A multicenter prospective study

The Journal of Pediatrics Jul 25, 2021

Tolia VN, Powers GC, Kelleher AS, et al. - Researchers conducted this prospective multicenter study to evaluate the rate of spontaneous closure and the incidence of adverse events in infants discharged home with a patent ductus arteriosus. The study included 201 premature infants (gestational age 23-32 weeks at birth) who were discharged home with a persistently patent ductus arteriosus (PDA) and had their PDA status checked at 6-month intervals until they were 18 months old. By one year, spontaneous closure of the PDA occurred in slightly less than half of premature infants discharged with a patent ductus, which was lower than previously reported. The high rate of assisted closure and/or adverse events in this population necessitates close monitoring after discharge.

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