Vaughan-Shaw PG, et al. - Researchers evaluated the impact of colorectal cancer (CRC) surgical resection on the level of perioperative plasma vitamin D (25OHD) and C-reactive protein (CRP) and investigated the connection between the level of circulating vitamin D and the survival of CRC. They sampled 92 patients who had CRC resection sequentially and measured plasma 25OHD and CRP. They tested 25OHD and CRP in two temporally distinct cohorts of patients with CRC (n=2006, n=2100) for survival analysis and investigated the association between survival outcome, vitamin D circulation and systemic inflammatory response. According to results, serial sampling of patients undergoing CRC resectional surgery shows that surgery leads to a fall in the level of plasma vitamin D, regardless of CRP response. Findings revealed that plasma 25OHD level is a low-25OHD prognostic biomarker associated with poorer survival, especially for those with GG genotype rs11568820. There is a compelling rationale for a randomized trial of vitamin D supplementation after CRC surgery.